Assessment of area conservation in the Arab-Islamic city: the case of historic Cairo

Historic Cairo is a significant medieval urban phenomenon that has suffered uninterrupted deterioration since the mid nineteenth century. This led to questioning the quality of area conservation schemes in Cairo. Are they superficial, focusing only on restoration, which limits the focus of conservation only to the physical aspects of historic areas? Are they only designed to attract tourist dollars regardless of other social and local cultural considerations? Could the financial deficiency be the main reason for such a continuing environmental decline as proclaimed by the planners and officials in charge of safeguarding Historic Cairo?All these questions besides many others inspired this investigation to explore the deficiencies and obstacles affecting area conservation in Historic Cairo. These questions are clustered into two main directions: the first focuses on the commission, i.e. the quality of executing area conservation schemes. The second searches for the reasons and goals for which the mission of a conservation scheme is pursued.The commission inquiry defines what to conserve, the most significant values and qualities that give a meaning to the historic area to be safeguarded as addressed in Chapters One and Two. It also investigates how to conserve these areas without jeopardising such environmental values and qualities, as elaborated in Chapters Three and Four. On the other hand, the mission inquiry is probed through indepth analysis of policies and the political model responsible for them in Egypt, as elaborated in Chapter Six.Since area conservation is still in its infancy in Historic Cairo, this research broadens its scope to investigate the Arab -Islamic Context. Through this broader context, many case studies were consulted along Chapters one to Four. These helped define comprehensive environmental assessment criteria, envisaged through a comprehensive sampling framework that incorporate all the active agents, based on integrating all the above environmental qualities, values and conservation and policy- making processes, as synthesised in Chapter Five.Such a comprehensive assessment model is the actual contribution of this research to area conservation general literature, through which it was possible to explore one of the most chaotic urban phenomena, Historic Cairo, as conducted in Chapter Six. The implications of such an investigation identified that historic areas in Cairo are not envisaged as the last refuge of traditional culture and lifestyle but rather as a potential venue to attract foreign currency through development for cultural tourism. In addition, the continuing environmental deterioration pointed above, is mainly due to inter governmental organisational conflicts, which cripple the conservation and urban upgrading process in Egypt in general

Perspective Chapter: The Toxic Silver (Hg)

In the late 1950s, residents of a Japanese fishing village known as “Minamata” began falling ill and dying at an alarming rate. The Japanese authorities stated that methyl-mercury-rich seafood and shellfish caused the sickness. Burning fossil fuels represent ≈52.7% of Hg emissions. The majorities of mercury’s compounds are volatile and thus travel hundreds of miles with wind before being deposited on the earth’s surface. High acidity and dissolved organic carbon increase Hg-mobility in soil to enter the food chain. Additionally, Hg is taken up by areal plant parts via gas exchange. Mercury has no identified role in plants while exhibiting high affinity to form complexes with soft ligands such as sulfur and this consequently inactivates amino acids and sulfur-containing antioxidants. Long-term human exposure to Hg leads to neurotoxicity in children and adults, immunological, cardiac, and motor reproductive and genetic disorders. Accordingly, remediating contaminated soils has become an obligation. Mercury, like other potentially toxic elements, is not biodegradable, and therefore, its remediation should encompass either removal of Hg from soils or even its immobilization. This chapter discusses Hg’s chemical behavior, sources, health dangers, and soil remediation methods to lower Hg levels

2018 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1005/thumbnail.jp

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box–Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM -loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds

The ESC ACCA EAPCI EORP acute coronary syndrome ST-elevation myocardial infarction registry

Aims: The Acute Cardiac Care Association (ACCA)-European Association of Percutaneous Coronary Intervention (EAPCI) Registry on ST-elevation myocardial infarction (STEMI) of the EurObservational programme (EORP) of the European Society of Cardiology (ESC) registry aimed to determine the current state of the use of reperfusion therapy in ESC member and ESC affiliated countries and the adherence to ESC STEMI guidelines in patients with STEMI. Methods and results: Between 1 January 2015 and 31 March 2018, a total of 11 462 patients admitted with an initial diagnosis of STEMI according to the 2012 ESC STEMI guidelines were enrolled. Individual patient data were collected across 196 centres and 29 countries. Among the centres, there were 136 percutaneous coronary intervention centres and 91 with cardiac surgery on-site. The majority of centres (129/196) were part of a STEMI network. The main objective of this study was to describe the demographic, clinical, and angiographic characteristics of patients with STEMI. Other objectives include to assess management patterns and in particular the current use of reperfusion therapies and to evaluate how recommendations of most recent STEMI European guidelines regarding reperfusion therapies and adjunctive pharmacological and non-pharmacological treatments are adopted in clinical practice and how their application can impact on patients' outcomes. Patients will be followed for 1 year after admission. Conclusion: The ESC ACCA-EAPCI EORP ACS STEMI registry is an international registry of care and outcomes of patients hospitalized with STEMI. It will provide insights into the contemporary patient profile, management patterns, and 1-year outcome of patients with STEMI